Good evidence supports acetaminophen as an effective and safe reliever of acute postoperative pain Critical Summary Prepared by: James Zahrowski DMD, MS, PharmD 

A Critical Summary of:

Single dose oral paracetamol (acetaminophen) for postoperative pain in adults

Toms L, McQuay HJ, Derry S, Moore RA. Cochrane Database Syst Rev. 2008;(4):CD004602

Published Date: 4/7/2010

This summary is published in the Journal of the American Dental Association and can be accessed at :-


  • Systematic Review Conclusion:

    A single standard dose of acetaminophen relieves moderate to severe postoperative pain in about one-half of adults for four hours with minimal adverse effects similar to those of placebo.

  • Critical Summary Assessment:

    An updated, high-quality systematic review of mostly high-quality evidence indicates that a standard dose of acetaminophen relieves postoperative pain safely for four hours without a dose-dependent effect on efficacy or duration of pain control.

  • Evidence Quality Rating:


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