Orally administered amoxicillin decreases the risk of implant failures Critical Summary Prepared by: Stacy Geisler DDS, PhD 

A Critical Summary of:

Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications

Esposito M, Grusovin MG, Talati M, Coulthard P, Oliver R, Worthington HV. Cochrane Database Syst Rev. 2008;(3):CD004152

Published Date: 3/22/2010

This summary is published in the Journal of the American Dental Association and can be accessed at :-


  • Systematic Review Conclusion:

    Evidence suggests that 2 grams of amoxicillin administered orally one hour before implant placement surgery significantly reduces the failure of dental implants placed in ordinary conditions.

  • Critical Summary Assessment:

    The authors conducted a meta-analysis of two clinical trials, resulting in a finding that antibiotics had a significant effect in decreasing the risk of implant failure.

  • Evidence Quality Rating:


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