Amoxicillin/metronidazole therapy may improve the effectiveness of scaling and root planing in patients with periodontitis: Chronic Critical Summary Prepared by: L. Virginia Powell DMD, GPR 

A Critical Summary of:

Effectiveness of systemic amoxicillin/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis

Sgolastra, Fabrizio, Gatto, Roberto, Petrucci, Ambra, Monaco, Annalisa. Journal of Periodontology. 2012;83(10):1257-69

Published Date: 6/3/2013

This summary is published in the Journal of the American Dental Association and can be accessed at :-


  • Systematic Review Conclusion:

    Preliminary evidence suggests scaling and root planing (SRP) in combination with amoxicillin (AMX)/metronidazole (MET) (SRP + AMX/MET) therapy may be more effective in treating chronic periodontitis (CP) than is SRP alone.

  • Critical Summary Assessment:

    Preliminary evidence from a meta-analysis of four randomized clinical trials (RCTs) seems to support the effectiveness of systemic AMX/MET therapy as an adjunct to SRP alone in treating CP, although safety data are incomplete.

  • Evidence Quality Rating:


Rate This Critical Summary

Information in the above "Rate the Critical Summary" box is used by the administrators of this Website to gauge the usefulness of Critical Summaries and make improvements to the program. If you have comments specific to this critical summary and would like to contact the editors, please  Send a Letter to the Editor


Letter to the Editor