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Amoxicillin/metronidazole therapy may improve the effectiveness of scaling and root planing in patients with periodontitis: Chronic Critical Summary Prepared by: L. Virginia Powell DMD, GPR 

A Critical Summary of:

Effectiveness of systemic amoxicillin/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis

Sgolastra, Fabrizio, Gatto, Roberto, Petrucci, Ambra, Monaco, Annalisa. Journal of Periodontology. 2012;83(10):1257-69

Published Date: 6/3/2013

This summary is published in the Journal of the American Dental Association and can be accessed at :-
http://jada.ada.org/content/144/6/640.full

OVERVIEW

  • Systematic Review Conclusion:

    Preliminary evidence suggests scaling and root planing (SRP) in combination with amoxicillin (AMX)/metronidazole (MET) (SRP + AMX/MET) therapy may be more effective in treating chronic periodontitis (CP) than is SRP alone.

  • Critical Summary Assessment:

    Preliminary evidence from a meta-analysis of four randomized clinical trials (RCTs) seems to support the effectiveness of systemic AMX/MET therapy as an adjunct to SRP alone in treating CP, although safety data are incomplete.

  • Evidence Quality Rating:

    Limited

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