Cryotherapy and keratinocyte growth factor may be beneficial in preventing oral mucositis in patients with cancer, and sucralfate is effective in reducing its severity Critical Summary Prepared by: Shukan Kanuga DDS, MSD 

A Critical Summary of:

Interventions for preventing oral mucositis for patients with cancer receiving treatment

Worthington, H. V., Clarkson, J. E., Bryan, G., Furness, S., Glenny, A. M., Littlewood, A., McCabe, M. G., Meyer, S., Khalid, T.. Cochrane Database of Systematic Reviews. 2010;12():CD000978

Published Date: 8/1/2013

This summary is published in the Journal of the American Dental Association and can be accessed at :-


  • Systematic Review Conclusion:

    Ten interventions were beneficial in preventing or reducing the severity of oral mucositis associated with cancer treatment. Both cryotherapy (ice chips) and keratinocyte growth factor (palifermin) used separately were the most beneficial in preventing oral mucositis. Sucralfate was effective in reducing the severity of mucositis.

  • Critical Summary Assessment:

    Ten interventions with varying levels of evidence had some benefits that helped prevent or reduce the severity of mucositis compared with placebos or no treatment.

  • Evidence Quality Rating:


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