Good evidence supports ibuprofen as an effective and safe analgesic for postoperative pain Critical Summary Prepared by: Arthur Jeske DMD, PhD; James Zahrowski DMD, MS, PharmD 

A Critical Summary of:

Single dose oral ibuprofen for acute postoperative pain in adults

Derry C, Derry S, Moore RA, McQuay HJ. Cochrane Database of Systematic Reviews. 2009;(3):CD001548

Published Date: 5/10/2010

This summary is published in the Journal of the American Dental Association and can be accessed at :-


  • Systematic Review Conclusion:

    Substantial evidence from multiple highquality randomized controlled trials (RCTs) and consistency across studies suggests single-dose ibuprofen effectively reduces acute moderate to severe postoperative pain in adults, with minimal adverse effects.

  • Critical Summary Assessment:

    A high-quality systematic review of 72 randomized
    controlled and generally well-designed trials (mostly high-quality and
    double-masked) suggests that single doses of ibuprofen 200 to 400 milligrams
    provide relief of acute moderate to severe postoperative pain for approximately
    five hours in 50 percent of adults. Higher doses increased the effectiveness.
    Adverse drug effects were uncommon and similar to those of placebo.

  • Evidence Quality Rating:


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