Amoxicillin/metronidazole therapy may improve the effectiveness of scaling and root planing in patients with periodontitis: Aggressive Critical Summary Prepared by: L. Virginia Powell DMD, GPR 

A Critical Summary of:

Effectiveness of systemic amoxicillin/metronidazole as an adjunctive therapy to full-mouth scaling and root planing in the treatment of aggressive periodontitis: a systematic review and meta-analysis

Sgolastra, F., Petrucci, A., Gatto, R., Monaco, A.. J Periodontol. 2012;83(6):731-43

Published Date: 6/3/2013

This summary is published in the Journal of the American Dental Association and can be accessed at :-


  • Systematic Review Conclusion:

    Full-mouth scaling and root planing (FMSRP) in combination with amoxicillin (AMX)/metronidazole (MET) (FMSRP + AMX/MET) therapy is more effective in treating generalized aggressive periodontitis (GAgP) than is FMSRP alone.

  • Critical Summary Assessment:

    The results of a meta-analysis of six randomized clinical trials (RCTs) of high quality support the use of AMX/MET therapy to increase the effectiveness of FMSRP in treating GAgP.

  • Evidence Quality Rating:


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