ADA - EBD::Systematic Reviews

Systematic Reviews: Pharmacology and Therapeutics

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Antibiotics, Antimicrobials and Antivirals

Fluoride

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Pain Relief

Antibiotics, Antimicrobials and Antivirals

Systematic Reviews

Critical Summary

Plain Language Summary

A meta-analysis of the published literature on the effectiveness of antimicrobial soaps
Montville, R., Schaffner, D. W., Montville, Rebecca, Schaffner, Donald W.. Journal of Food Protection. ;74(11):1875-82

Evidence grade associating periodontitis with preterm birth and/or low birth weight: II: a systematic review of randomized trials evaluating the effects of periodontal treatment
Chambrone, L., Pannuti, C. M., Guglielmetti, M. R., Chambrone, L. A., Chambrone, Leandro, Pannuti, Claudio Mendes, Guglielmetti, Mariana Rocha, Chambrone, Luiz Armando. Journal of Clinical Periodontology. ;38(10):902-14

Antibiotics to prevent complications following tooth extractions
Lodi, G., Figini, L., Sardella, A., Carrassi, A., Del Fabbro, M., Furness, S.. Cochrane Database Syst Rev. 2012;11():CD003811

Antimicrobial or subantimicrobial antibiotic therapy as an adjunct to the nonsurgical periodontal treatment: a meta-analysis
Moreno Villagrana, Ana Patricia, Gomez Clavel, Jose Francisco. ISRN Dentistry. 2012;2012():581207

Effectiveness of systemic amoxicillin/metronidazole as adjunctive therapy to scaling and root planing in the treatment of chronic periodontitis: a systematic review and meta-analysis
Sgolastra, Fabrizio, Gatto, Roberto, Petrucci, Ambra, Monaco, Annalisa. Journal of Periodontology. 2012;83(10):1257-69

Effectiveness of systemic amoxicillin/metronidazole as an adjunctive therapy to full-mouth scaling and root planing in the treatment of aggressive periodontitis: a systematic review and meta-analysis
Sgolastra, F., Petrucci, A., Gatto, R., Monaco, A.. J Periodontol. 2012;83(6):731-43

Effects of antibiotics on dental implants: a review
Ahmad, Nabeel, Saad, Najeeb. Journal of Clinical Medicine Research. 2012;4(1):1-6

Interventions for treating oral lichen planus: a systematic review
Lodi, G., Carrozzo, M., Furness, S., Thongprasom, K.. British Journal of Dermatology. 2012;166(5):938-47

Non-surgical therapy for the management of peri-implantitis: a systematic review
Muthukuru, Manoj, Zainvi, Arbia, Esplugues, Enrique O., Flemmig, Thomas F.. Clinical Oral Implants Research. 2012;23 Suppl 6():77-83

Combined antiviral therapy of hepatitis C virus in dialysis patients: meta-analysis of clinical trials
Fabrizi, F., Dixit, V., Martin, P., Messa, P.. Journal of Viral Hepatitis. 2011;18(7):e263-9

Effectiveness of postoperative antibiotics in orthognathic surgery: a meta-analysis
Danda, A. K., Ravi, P.. Journal of Oral & Maxillofacial Surgery. 2011;69(10):2650-6

Meta-analysis: insulin resistance and sustained virological response in hepatitis C
Eslam, M., Aparcero, R., Kawaguchi, T., Del Campo, J. A., Sata, M., Khattab, M. A., Romero-Gomez, M.. Alimentary Pharmacology & Therapeutics. 2011;34(3):297-305

Perioperative antibiotic prophylaxis in orthognathic surgery: a systematic review and meta-analysis of clinical trials
Tan, S. K., Lo, J., Zwahlen, R. A.. Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics. 2011;112(1):19-27

Stable bone density in HAART-treated individuals with HIV: a meta-analysis
Bolland, M. J., Wang, T. K., Grey, A., Gamble, G. D., Reid, I. R.. Journal of Clinical Endocrinology & Metabolism. 2011;96(9):2721-31

Use of antibiotics in the treatment of mandible fractures: a systematic review
Kyzas, P. A.. Journal of Oral & Maxillofacial Surgery. 2011;69(4):1129-45

Amoxicillin/metronidazole or scaling and root planing in the treatment of chronic periodontitis
Bono, A., Brunotto, M.. Acta Odontologica Latinoamericana. 2010;23(3):196-203

Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications
Esposito M, Worthington HV, Loli V, Coulthard P, Grusovin MG. Cochrane Database of Systematic Reviews. 2010;7():CD004152

An evidence-based assessment of the clinical guidelines for replanted avulsed teeth. Part II: prescription of systemic antibiotics
Hinckfuss SE, Messer LB. Dental Traumatology. 2009;25(2):158-64

Chlorhexidine in the prevention of dry socket: effectiveness of different dosage forms and regimens
Minguez-Serra MP, Salort-Llorca C, Silvestre-Donat FJ. Medicina Oral, Patologia Oral y Cirugia Bucal. 2009;14(9):e445-9

Short versus standard duration antibiotic therapy for acute streptococcal pharyngitis in children
Altamimi S, Khalil A, Khalaiwi KA, Milner R, Pusic MV, Al Othman MA. Cochrane Database of Systematic Reviews. 2009;(1):CD004872

Acyclovir for treating primary herpetic gingivostomatitis
Nasser M, Fedorowicz Z, Khoshnevisan MH, Shahiri Tabarestani M. Cochrane Database of Systematic Reviews. 2008;(4):CD006700

Antibiotics for acute maxillary sinusitis
Ahovuo-Saloranta A, Borisenko OV, Kovanen N, Varonen H, Rautakorpi UM, Williams JW Jr, Makela M. Cochrane Database Syst Rev. 2008;(2):CD000243

Antibiotics for the prophylaxis of bacterial endocarditis in dentistry
Oliver R, Roberts GJ, Hooper L, Worthington HV. Cochrane Database Syst Rev. 2008;(4):CD003813

Antiviral therapy for Ramsay Hunt syndrome (herpes zoster oticus with facial palsy) in adults
Uscategui T, Doree C, Chamberlain IJ, Burton MJ. Cochrane Database of Systematic Reviews. 2008;(4):CD006851

Efficacy of AZM therapy in patients with gingival overgrowth induced by Cyclosporine A: a systematic review
Clementini M, Vittorini G, Crea A, Gualano MR, Macri LA, Deli G, La Torre G. BMC Oral Health. 2008;8():34

Interventions for replacing missing teeth: antibiotics at dental implant placement to prevent complications
Esposito M, Grusovin MG, Talati M, Coulthard P, Oliver R, Worthington HV. Cochrane Database Syst Rev. 2008;(3):CD004152

The efficacy of antibiotic prophylaxis at placement of dental implants: a Cochrane systematic review of randomised controlled clinical trials
Esposito M, Grusovin MG, Coulthard P, Oliver R, Worthington HV. European Journal of Oral Implantology. 2008;1(2):95-103

Use of prophylactic antibiotic therapy in oral surgical procedures: a critical review
Guerrero JS. Journal of the California Dental Association. 2008;36(12):943-50

Effectiveness of antibiotic prophylaxis in third molar surgery: a meta-analysis of randomized controlled clinical trials
Ren YF, Malmstrom HS. J Oral Maxillofac Surg. 2007;65(10):1909-21

Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group
Wilson, W., Taubert, K. A., Gewitz, M., Lockhart, P. B., Baddour, L. M., Levison, M., Bolger, A., Cabell, C. H., Takahashi, M., Baltimore, R. S., Newburger, J. W., Strom, B. L., Tani, L. Y., Gerber, M.. Journal of the American Dental Association. 2007;138(6):739-45

The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: A systematic review of the literature
Ribeiro LG, Hashizume LN, Maltz M. J Dent. 2007;35(5):359-70

The evidence base for the efficacy of antibiotic prophylaxis in dental practice
Lockhart PB, Loven B, Brennan MT, Fox PC. J Am Dent Assoc. 2007;138(4):458-74; quiz 534-5, 437

Topical chlorhexidine for prevention of ventilator-associated pneumonia: a meta-analysis
Chlebicki MP, Safdar N. Crit Care Med. 2007;35(2):595-602

A Cochrane systematic review finds no evidence to support the use of antibiotics for pain relief in irreversible pulpitis
Keenan JV, Farman AG, Fedorowicz Z, Newton JT. J Endod. 2006;32(2):87-92

A systematic review of prophylactic antibiotics in the surgical treatment of maxillofacial fractures
Andreasen JO, Jensen SS, Schwartz O, Hillerup Y. J Oral Maxillofac Surg. 2006;64(11):1664-8

A systematic review on the effects of the chlorhexidine chip when used as an adjunct to scaling and root planing in the treatment of chronic periodontitis
Cosyn J, Wyn I. J Periodontol. 2006;77(2):257-64

A systematic review on the effects of subgingival chlorhexidine gel administration in the treatment of chronic periodontitis
Cosyn J, Sabzevar MM. J Periodontol. 2005;76(11):1805-13

Antibiotic use for irreversible pulpitis
Keenan JV, Farman AG, Fedorowicz Z, Newton JT. Cochrane Database Syst Rev. 2005;(2):CD004969

Higher dosages of azithromycin are more effective in treatment of group A streptococcal tonsillopharyngitis
Casey JR, Pichichero ME. Clin Infect Dis. 2005;40(12):1748-55

Impact of local adjuncts to scaling and root planing in periodontal disease therapy: a systematic review
Bonito AJ, Lux L, Lohr KN. J Periodontol. 2005;76(8):1227-36

Metaanalysis of short course antibiotic treatment for group a streptococcal tonsillopharyngitis
Casey JR, Pichichero ME. Pediatr Infect Dis J. 2005;24(10):909-17

Prevention of alveolar osteitis with chlorhexidine: a meta-analytic review
Caso A, Hung LK, Beirne OR. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99(2):155-9

Reducing the risk of deep wound infection in primary joint arthroplasty with antibiotic bone cement
Block JE, Stubbs HA. Orthopedics. 2005;28(11):1334-45

Antibiotic prophylaxis in dialysis patients undergoing invasive dental treatment
Tong DC, Walker RJ. Nephrology (Carlton). 2004;9(3):167-70

Antimicrobial treatment of peri-implant diseases
Heitz-Mayfield LJ, Lang NP. Int J Oral Maxillofac Implants. 2004;19 Suppl():128-39

Systemic antibiotics in the management of chronic periodontitis
Preshaw PM. Eur J Prosthodont Restor Dent. 2004;12(2):63-9

Antibiotic prophylaxis for patients with joint prostheses - still a dilemma for dental practitioners
Seymour RA, Whitworth JM, Martin M. Br Dent J. 2003;194(12):649-53

Local anti-infective therapy: pharmacological agents. A systematic review
Hanes PJ, Purvis JP. Ann Periodontol. 2003;8(1):79-98

Meta-analysis of local tetracycline in treating chronic periodontitis
Pavia M, Nobile CG, Angelillo IF. J Periodontol. 2003;74(6):916-32

Systemic anti-infective periodontal therapy. A systematic review
Haffajee AD, Socransky SS, Gunsolley JC. Ann Periodontol. 2003;8(1):115-81

A systematic review of the effect of anti-infective therapy in the treatment of peri-implantitis
Klinge B, Gustafsson A, Berglundh T. J Clin Periodontol. 2002;29 Suppl 3():213-25; discussion 232-3

A systematic review on the effect of systemic antimicrobials as an adjunct to scaling and root planing in periodontitis patients
Herrera D, Sanz M, Jepsen S, Needleman I, Roldan S. J Clin Periodontol. 2002;29 Suppl 3():136-59; discussion 160-2

Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review
Blum IR. Int J Oral Maxillofac Surg. 2002;31(3):309-17

Periodontal therapy using local delivery of antimicrobial agents
Niederman R, Abdelshehid G, Goodson JM. Dent Clin North Am. 2002;46(4):665-77, viii

Implementing practice guidelines for appropriate antimicrobial usage: a systematic review
Gross PA, Pujat D. Med Care. 2001;39(8 Suppl 2):II55-69

Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for upper respiratory tract infections
Ioannidis JP, Contopoulos-Ioannidis DG, Chew P, Lau J. J Antimicrob Chemother. 2001;48(5):677-89

Systematic review and meta-analysis of antibiotic therapy for bone and joint infections
Stengel D, Bauwens K, Sehouli J, Ekkernkamp A, Porzsolt F. Lancet Infect Dis. 2001;1(3):175-88

Prophylactic use of antibiotics for procedures after total joint replacement
Deacon JM, Pagliaro AJ, Zelicof SB, Horowitz HW. J Bone Joint Surg Am. 1996;78(11):1755-70

Quality assessment and meta-analysis of systemic tetracycline use in chronic adult periodontitis
Hayes C, Antczak-Bouckoms A, Burdick E. J Clin Periodontol. 1992;19(3):164-8

Fluoride

Systematic Reviews

Critical Summary

Plain Language Summary

Interventions for the management of dry mouth: topical therapies
Furness, S., Worthington, H. V., Bryan, G., Birchenough, S., McMillan, R., Furness, Susan, Worthington, Helen V., Bryan, Gemma, Birchenough, Sarah, McMillan, Roddy. Cochrane Database of Systematic Reviews. ;12():CD008934

Anticariogenic effect of xylitol versus fluoride - a quantitative systematic review of clinical trials
Mickenautsch, Steffen, Yengopal, Veerasamy. International Dental Journal. 2012;62(1):6-20

Informing evidence-based clinical practice guidelines for children with cerebral palsy at risk of osteoporosis: a systematic review
Fehlings, Darcy, Switzer, Lauren, Agarwal, Payal, Wong, Charles, Sochett, Etienne, Stevenson, Richard, Sonnenberg, Lyn, Smile, Sharon, Young, Elizabeth, Huber, Joelene, Milo-Manson, Golda, Kuwaik, Ghassan Abu, Gaebler, Deborah. Developmental Medicine & Child Neurology. 2012;54(2):106-16

Evidence-based clinical recommendations regarding fluoride intake from reconstituted infant formula and enamel fluorosis: a report of the American Dental Association Council on Scientific Affairs
Berg, J., Gerweck, C., Hujoel, P. P., King, R., Krol, D. M., Kumar, J., Levy, S., Pollick, H., Whitford, G. M., Strock, S., Aravamudhan, K., Frantsve-Hawley, J., Meyer, D. M.. Journal of the American Dental Association. 2011;142(1):79-87

Supplemental fluoride use for moderate and high caries risk adults: a systematic review
Gibson, G., Jurasic, M. M., Wehler, C. J., Jones, J. A.. Journal of Public Health Dentistry. 2011;71(3):171-84

Salt fluoridation: a meta-analysis of its efficacy for caries prevention
Yengopal V, Chikte UM, Mickenautsch S, Oliveira LB, Bhayat A, Chikte UME. SADJ. 2010;65(2):60-4

Topical fluoride as a cause of dental fluorosis in children
Wong MC, Glenny AM, Tsang BW, Lo EC, Worthington HV, Marinho VC, Glenny A-M. Cochrane Database of Systematic Reviews. 2010;(1):CD007693

Caries prevention with fluoride toothpaste in children: an update
Twetman S. European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry. 2009;10(3):162-7

Caries preventive effect of fluoride in milk, salt and tablets: a literature review
Espelid I. European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry. 2009;10(3):149-56

Cochrane reviews of randomized trials of fluoride therapies for preventing dental caries
Marinho VCC. European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry. 2009;10(3):183-91

Infant formula and enamel fluorosis: a systematic review.[see comment]
Hujoel PP, Zina LG, Moimaz SAS, Cunha-Cruz J. Journal of the American Dental Association. 2009;140(7):841-54

Water fluoridation
Parnell C, Whelton H, O'Mullane D. European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry. 2009;10(3):141-8

A systematic review of the efficacy and safety of fluoridation
Yeung CA. Evid Based Dent. 2008;9(2):39-43

Fluoride and children's intelligence: a meta-analysis
Tang QQ, Du J, Ma HH, Jiang SJ, Zhou XJ. Biological Trace Element Research. 2008;126(1-3):115-20

Fluoride varnish in the prevention of dental caries in children and adolescents: a systematic review
Azarpazhooh A, Main PA. J Can Dent Assoc. 2008;74(1):73-9

Professionally applied topical fluoride: evidence-based clinical recommendations
American Dental Association Council on Scientific, Affairs. Journal of the American Dental Association. 2006;137(8):1151-9

Fluoridated milk for preventing dental caries
Yeung CA, Hitchings JL, Macfarlane TV, Threlfall AG, Tickle M, Glenny AM. Cochrane Database Syst Rev. 2005;(3):CD003876

Global trends in dental fluorosis from 1980 to 2000: a systematic review
Khan A, Moola MH, Cleaton-Jones P. SADJ. 2005;60(10):418-21

Effect of 1000 ppm relative to 250 ppm fluoride toothpaste. A meta-analysis
Steiner M, Helfenstein U, Menghini G. Am J Dent. 2004;17(2):85-8

Systematic review of studies comparing the anti-caries efficacy of children's toothpaste containing 600 ppm of fluoride or less with high fluoride toothpastes of 1,000 ppm or above
Ammari AB, Bloch-Zupan A, Ashley PF. Caries Res. 2003;37(2):85-92

Association of Down's syndrome and water fluoride level: a systematic review of the evidence
Whiting P, MacDonagh M, Kleijnen J. BMC Public Health. 2001;1():6

How to measure the effects of fluoride treatments in clinical trials? The role of caries prevalence and caries assessment
Reich E. Caries Res. 2001;35 Suppl 1():34-9

Reduction in dental caries with four concentrations of sodium fluoride in a dentifrice: a meta-analysis evaluation
Bartizek RD, Gerlach RW, Faller RV, Jacobs SA, Bollmer BW, Biesbrock AR. J Clin Dent. 2001;12(3):57-62

Water fluoridation, osteoporosis, fractures--recent developments
Demos LL, Kazda H, Cicuttini FM, Sinclair MI, Fairley CK. Aust Dent J. 2001;46(2):80-7; quiz 143

Water fluoridation. Meta-analysis of fluoridation and fractures has been done
Jones G. BMJ. 2001;322(7300):1486; author reply 1487-8

Systematic review of public water fluoridation
Holloway PJ. Community Dent Health. 2000;17(4):261-2

Systematic review of water fluoridation
McDonagh MS, Whiting PF, Wilson PM, Sutton AJ, Chestnutt I, Cooper J, Misso K, Bradley M, Treasure E, Kleijnen J. BMJ. 2000;321(7265):855-9

"Risk periods" associated with the development of dental fluorosis in maxillary permanent central incisors: a meta-analysis
Bardsen A. Acta Odontol Scand. 1999;57(5):247-56

Fluoride supplements and fluorosis: a meta-analysis
Ismail AI, Bandekar RR. Community Dent Oral Epidemiol. 1999;27(1):48-56

Water fluoridation, bone mass and fracture: a quantitative overview of the literature
Jones G, Riley M, Couper D, Dwyer T. Aust N Z J Public Health. 1999;23(1):34-40

Fluoride toothpastes, rinses, and tablets
Stephen KW. Adv Dent Res. 1994;8(2):185-9

Sodium fluoride or sodium monofluorophosphate? A critical view of a meta-analysis on their relative effectiveness in dentifrices
Holloway PJ, Worthington HV. Am J Dent. 1993;6 Spec No():S55-8

The comparative clinical cariostatic efficacy of sodium fluoride and sodium monofluorophosphate dentifrices: a review of trials
Beiswanger BB, Stookey GK. ASDC J Dent Child. 1989;56(5):337-47

Misc

Systematic Reviews

Critical Summary

Plain Language Summary

Calcium supplements and risk of myocardial infarction: a hypothesis formulated but not yet adequately tested
Hennekens, C. H., Barice, E. J., Hennekens, Charles H., Barice, E. Joan. American Journal of Medicine. ;124(12):1097-8

Cost effectiveness of interventions to reduce relapse to smoking following smoking cessation
Taylor, M., Leonardi-Bee, J., Agboola, S., McNeill, A., Coleman, T., Taylor, Matthew, Leonardi-Bee, Jo, Agboola, Shade, McNeill, Ann, Coleman, Tim. Addiction. ;106(10):1819-26

Gastrointestinal adverse effects of varenicline at maintenance dose: a meta-analysis
Leung, L. K., Patafio, F. M., Rosser, W. W., Leung, Lawrence K., Patafio, Francis M., Rosser, Walter W.. BMC Clinical Pharmacology. ;11():15

Smoking cessation telephone quitlines effective regardless of recruitment method
Barton, M. K., Barton, Mary Kay. CA: a Cancer Journal for Clinicians. ;61(6):361-2

Topiramate versus carbamazepine for the treatment of classical trigeminal neuralgia: a meta-analysis
Wang, Q. P., Bai, M., Wang, Qiang-Ping, Bai, Min. CNS Drugs. ;25(10):847-57

A systematic review on survival and success rates of implants placed immediately into fresh extraction sockets after at least 1 year
Lang, Niklaus P., Pun, Lui, Lau, Ka Yee, Li, Ka Yan, Wong, May C. M.. Clinical Oral Implants Research. 2012;23 Suppl 5():39-66

Anticariogenic effect of xylitol versus fluoride - a quantitative systematic review of clinical trials
Mickenautsch, Steffen, Yengopal, Veerasamy. International Dental Journal. 2012;62(1):6-20

Candidiasis (oropharyngeal)
Pankhurst, Caroline L.. Clinical Evidence. 2012;():

Chlorhexidine for the prevention of alveolar osteitis
Yengopal, V., Mickenautsch, S.. International Journal of Oral & Maxillofacial Surgery. 2012;41(10):1253-64

Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review
Van Strydonck, Danielle A. C., Slot, Dagmar E., Van der Velden, Ubele, Van der Weijden, Fridus. Journal of Clinical Periodontology. 2012;39(11):1042-55

Effect of anti-rheumatic agents on periodontal parameters and biomarkers of inflammation: a systematic review and meta-analysis
Han, Ji Young, Reynolds, Mark A.. Journal of Periodontal & Implant Science. 2012;42(1):3-12

Effect of teriparatide on bone mineral density and fracture in postmenopausal osteoporosis: meta-analysis of randomised controlled trials
Han, S. L., Wan, S. L.. International Journal of Clinical Practice. 2012;66(2):199-209

Inferior or double joint spaces injection versus superior joint space injection for temporomandibular disorders: a systematic review and meta-analysis
Li, Chunjie, Zhang, Yifan, Lv, Jun, Shi, Zongdao. Journal of Oral & Maxillofacial Surgery. 2012;70(1):37-44

Meta-analysis: oral bisphosphonates and the risk of oesophageal cancer
Andrici, J., Tio, M., Eslick, G. D.. Alimentary Pharmacology & Therapeutics. 2012;36(8):708-16

Mouthwash and Oral Cancer Risk Quantitative Meta-analysis of Epidemiologic Studies
Gandini, Sara, Negri, Eva, Boffetta, Paolo, La Vecchia, Carlo, Boyle, Peter. Annals of Agricultural & Environmental Medicine. 2012;19(2):173-80

Oral health promotion interventions on oral reservoirs of staphylococcus aureus: a systematic review
Lam, O. L. T., McGrath, C., Bandara, H. M. H. N., Li, L. S. W., Samaranayake, L. P.. Oral Diseases. 2012;18(3):244-54

Systematic review of the cost-effectiveness of varenicline vs. bupropion for smoking cessation
Mahmoudi, M., Coleman, C. I., Sobieraj, D. M.. International Journal of Clinical Practice. 2012;66(2):171-82

Topical nonsteroidal anti-inflammatory medications for treatment of temporomandibular joint degenerative pain: a systematic review
Senye, Mireya, Mir, Carlos Flores, Morton, Stephanie, Thie, Norman M.. Journal of Orofacial Pain. 2012;26(1):26-32

A systematic review with meta-analysis of the effect of low-level laser therapy (LLLT) in cancer therapy-induced oral mucositis
Bjordal, J. M., Bensadoun, R. J., Tuner, J., Frigo, L., Gjerde, K., Lopes-Martins, R. A.. Supportive Care in Cancer. 2011;19(8):1069-77

Bone graft substitutes in hip revision surgery: a comprehensive overview
Beswick, A., Blom, A. W.. Injury. 2011;42 Suppl 2():S40-6

Combined antiviral therapy of hepatitis C virus in dialysis patients: meta-analysis of clinical trials
Fabrizi, F., Dixit, V., Martin, P., Messa, P.. Journal of Viral Hepatitis. 2011;18(7):e263-9

Influence of adipokines and ghrelin on bone mineral density and fracture risk: a systematic review and meta-analysis
Biver, E., Salliot, C., Combescure, C., Gossec, L., Hardouin, P., Legroux-Gerot, I., Cortet, B.. Journal of Clinical Endocrinology & Metabolism. 2011;96(9):2703-13

Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): a comprehensive analysis by tumour site
Blanchard, P., Baujat, B., Holostenco, V., Bourredjem, A., Baey, C., Bourhis, J., Pignon, J. P., Mach-Ch Collaborative group. Radiotherapy & Oncology. 2011;100(1):33-40

The effect of chlorhexidine varnish on root caries: a systematic review
Slot, D. E., Vaandrager, N. C., Van Loveren, C., Van Palenstein Helderman, W. H., Van der Weijden, G. A.. Caries Research. 2011;45(2):162-73

The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review
Afennich, F., Slot, D. E., Hossainian, N., Van der Weijden, G. A.. International Journal of Dental Hygiene. 2011;9(3):182-90

The effects of hydrogen peroxide mouthwashes on the prevention of plaque and gingival inflammation: a systematic review
Hossainian, N., Slot, D. E., Afennich, F., Van der Weijden, G. A.. International Journal of Dental Hygiene. 2011;9(3):171-81

The impact of pharmacist interventions on osteoporosis management: a systematic review
Elias, M. N., Burden, A. M., Cadarette, S. M.. Osteoporosis International. 2011;22(10):2587-96

Amoxicillin/metronidazole or scaling and root planing in the treatment of chronic periodontitis
Bono, A., Brunotto, M.. Acta Odontologica Latinoamericana. 2010;23(3):196-203

Epidermal growth factor receptor targeted therapy in stages III and IV head and neck cancer
Cripps, C., Winquist, E., Devries, M. C., Stys-Norman, D., Gilbert, R., Head,, Neck Cancer Disease Site, Group. Current Oncology. 2010;17(3):37-48

The effect of antisialogogues in dentistry: a systematic review with a focus on bond failure in orthodontics
Kuijpers, M. A., Vissink, A., Ren, Y., Kuijpers-Jagtman, A. M.. Journal of the American Dental Association. 2010;141(8):954-65

Dental surgery for patients on anticoagulant therapy with warfarin: a systematic review and meta-analysis
Nematullah A, Alabousi A, Blanas N, Douketis JD, Sutherland SE. Journal. 2009;75(1):41

Medication effects on the rate of orthodontic tooth movement: a systematic literature review
Bartzela T, Turp JC, Motschall E, Maltha JC. American Journal of Orthodontics & Dentofacial Orthopedics. 2009;135(1):16-26

What influence do anticoagulants have on oral implant therapy? A systematic review
Madrid C, Sanz M. Clinical Oral Implants Research. 2009;20 Suppl 4():96-106

Corticosteroids reduce postoperative morbidity after third molar surgery: a systematic review and meta-analysis
Markiewicz MR, Brady MF, Ding EL, Dodson TB. J Oral Maxillofac Surg. 2008;66(9):1881-94

Efficacy of sodium hypochlorite and chlorhexidine against Enterococcus faecalis--a systematic review
Estrela C, Silva JA, de Alencar AH, Leles CR, Decurcio DA. Journal of Applied Oral Science. 2008;16(6):364-8

Interventions for preventing oral candidiasis for patients with cancer receiving treatment
Clarkson JE, Worthington HV, Eden OB. Cochrane Database Syst Rev. 2007;(1):CD003807

Management of dental patients taking common hemostasis-altering medications
Aframian DJ, Lalla RV, Peterson DE. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103 Suppl():S45 e1-11

An exposure-based risk assessment approach to confirm the safety of hydrogen peroxide for use in home tooth bleaching
Mahony C, Felter SP, McMillan DA. Regul Toxicol Pharmacol. 2006;44(2):75-82

Hemostatic mouthwashes in anticoagulated patients undergoing dental extraction
Patatanian E, Fugate SE. Ann Pharmacother. 2006;40(12):2205-10

Host response modulation in the management of periodontal diseases
Salvi GE, Lang NP. J Clin Periodontol. 2005;32 Suppl 6():108-29

Iodine supplementation for preventing iodine deficiency disorders in children
Angermayr L, Clar C. Cochrane Database Syst Rev. 2004;(2):CD003819

Meta-analysis of local metronidazole in the treatment of chronic periodontitis
Pavia M, Nobile CG, Bianco A, Angelillo IF. J Periodontol. 2004;75(6):830-8

The effectiveness of a toothpaste containing triclosan and polyvinyl-methyl ether maleic acid copolymer in improving plaque control and gingival health: a systematic review
Davies RM, Ellwood RP, Davies GM. J Clin Periodontol. 2004;31(12):1029-33

A systematic review for evidence of efficacy of anticholinergic drugs to treat drooling
Jongerius PH, van Tiel P, van Limbeek J, Gabreels FJ, Rotteveel JJ. Arch Dis Child. 2003;88(10):911-4

Efficacy of chemical root surface modifiers in the treatment of periodontal disease. A systematic review
Mariotti A. Ann Periodontol. 2003;8(1):205-26

Pharmacologic interventions in the treatment of temporomandibular disorders, atypical facial pain, and burning mouth syndrome. A qualitative systematic review
List T, Axelsson S, Leijon G. J Orofac Pain. 2003;17(4):301-10

Therapeutic use of hyperbaric oxygen for irradiated dental implant patients: a systematic review
Coulthard P, Esposito M, Worthington HV, Jokstad A. J Dent Educ. 2003;67(1):64-8

A systematic review of cardiovascular effects of epinephrine on hypertensive dental patients
Bader JD, Bonito AJ, Shugars DA. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;93(6):647-53

A systematic review of the management of oral candidiasis associated with HIV/AIDS
Albougy HA, Naidoo S. SADJ. 2002;57(11):457-66

A systematic review of the effectiveness of antifungal drugs for the prevention and treatment of oropharyngeal candidiasis in HIV-positive patients
Patton LL, Bonito AJ, Shugars DA. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92(2):170-9

A review of perioperative corticosteroid use in dentoalveolar surgery
Alexander RE, Throndson RR. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90(4):406-15

Interventions for treating oral lichen planus
Chan ES, Thornhill M, Zakrzewska J. Cochrane Database Syst Rev. 2000;(2):CD001168

Meta-analysis of the effect of systemic metronidazole as an adjunct to scaling and root planing for adult periodontitis
Elter JR, Lawrence HP, Offenbacher S, Beck JD. J Periodontal Res. 1997;32(6):487-96

Pain Relief

Systematic Reviews

Critical Summary

Plain Language Summary

Interventions for the management of temporomandibular joint osteoarthritis
de Souza, Raphael Freitas, Lovato da Silva, Claudia H., Nasser, Mona, Fedorowicz, Zbys, Al-Muharraqi, Mohammed A.. Cochrane Database of Systematic Reviews. 2012;4():CD007261

Interventions for treating oral lichen planus: a systematic review
Lodi, G., Carrozzo, M., Furness, S., Thongprasom, K.. British Journal of Dermatology. 2012;166(5):938-47

Pharmacological management of pain during orthodontic treatment: a meta-analysis
Angelopoulou, M. V., Vlachou, V., Halazonetis, D. J.. Orthodontics & Craniofacial Research. 2012;15(2):71-83

Preoperative analgesics for additional pain relief in children and adolescents having dental treatment
Ashley, Paul F., Parekh, Susan, Moles, David R., Anand, Prabhleen, Behbehani, Amal. Cochrane Database of Systematic Reviews. 2012;9():CD008392

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers)
Brocklehurst, Paul, Tickle, Martin, Glenny, Anne-Marie, Lewis, Michael A., Pemberton, Michael N., Taylor, Jennifer, Walsh, Tanya, Riley, Philip, Yates, Julian M.. Cochrane Database of Systematic Reviews. 2012;9():CD005411

Botulinum toxin treatment of secondary headaches and cranial neuralgias: a review of evidence
Linde, M., Hagen, K., Stovner, L. J.. Acta Neurologica Scandinavica. 2011;Supplementum.(191):50-5

Combination therapy for pain management in inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis)
Ramiro, S., Radner, H., van der Heijde, D., van Tubergen, A., Buchbinder, R., Aletaha, D., Landewe, R. B.. Cochrane Database of Systematic Reviews. 2011;(10):CD008886

Complications following autologous bone graft harvesting from the iliac crest and using the RIA: a systematic review
Dimitriou, R., Mataliotakis, G. I., Angoules, A. G., Kanakaris, N. K., Giannoudis, P. V.. Injury. 2011;42 Suppl 2():S3-15

Single dose oral analgesics for acute postoperative pain in adults
Moore, R. A., Derry, S., McQuay, H. J., Wiffen, P. J.. Cochrane Database of Systematic Reviews. 2011;9():CD008659

Single dose oral fenoprofen for acute postoperative pain in adults
Traa, M. X., Derry, S., Moore, R. A.. Cochrane Database of Systematic Reviews. 2011;2():CD007556

Single dose oral mefenamic acid for acute postoperative pain in adults
Moll, R., Derry, S., Moore, R. A., McQuay, H. J.. Cochrane Database of Systematic Reviews. 2011;3():CD007553

The efficacy of anticonvulsants on orofacial pain: a systematic review
Martin, W. J., Forouzanfar, T.. Oral Surgery Oral Medicine Oral Pathology Oral Radiology & Endodontics. 2011;111(5):627-33

A risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine
Palmer, H., Graham, G., Williams, K., Day, R.. Pain Medicine. 2010;11(6):951-65

Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain
Ong CK, Seymour RA, Lirk P, Merry AF. Anesth Analg. 2010;110(4):1170-9

Pharmacological interventions for pain in patients with temporomandibular disorders
Mujakperuo, H. R., Watson, M., Morrison, R., Macfarlane, T. V.. Cochrane Database of Systematic Reviews. 2010;(10):CD004715

Single dose oral codeine, as a single agent, for acute postoperative pain in adults
Derry S, Moore RA, McQuay HJ. Cochrane Database of Systematic Reviews. 2010;4():CD008099

Single dose oral gabapentin for established acute postoperative pain in adults
Straube S, Derry S, Moore RA, Wiffen PJ, McQuay HJ. Cochrane Database of Systematic Reviews. 2010;5():CD008183

Single dose oral ketoprofen and dexketoprofen for acute postoperative pain in adults
Barden J, Derry S, McQuay HJ, Moore RA. Cochrane Database of Systematic Reviews. 2009;(4):CD007355

Single dose oral lornoxicam for acute postoperative pain in adults
Hall PE, Derry S, Moore RA, McQuay HJ. Cochrane Database of Systematic Reviews. 2009;(4):CD007441

Single dose oral paracetamol (acetaminophen) with codeine for postoperative pain in adults
Toms L, Derry S, Moore RA, McQuay HJ. Cochrane Database Syst Rev. 2009;(1):CD001547

Single dose oral rofecoxib for acute postoperative pain in adults
Bulley S, Derry S, Moore RA, McQuay HJ. Cochrane Database of Systematic Reviews. 2009;(4):CD004604

Single dose oral paracetamol (acetaminophen) for postoperative pain in adults
Toms L, McQuay HJ, Derry S, Moore RA. Cochrane Database Syst Rev. 2008;(4):CD004602

COX-2 selective inhibitors: a literature review of analgesic efficacy and safety in oral-maxillofacial surgery
Cicconetti A, Bartoli A, Ripari F, Ripari A. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97(2):139-46

Relative efficacy of oral analgesics after third molar extraction
Barden J, Edwards JE, McQuay HJ, Wiffen PJ, Moore RA. Br Dent J. 2004;197(7):407-11; discussion 397

The efficacy of non-opioid analgesics for postoperative dental pain: a meta-analysis
Ahmad N, Grad HA, Haas DA, Aronson KJ, Jokovic A, Locker D. SAAD Dig. 2000;17(1):20

Topical medications for orofacial neuropathic pain: a review
Padilla M, Clark GT, Merrill RL. J Am Dent Assoc. 2000;131(2):184-95

Pain-mediated altered absorption and metabolism of ibuprofen: an explanation for decreased serum enantiomer concentration after dental surgery
Jamali F, Kunz-Dober CM. Br J Clin Pharmacol. 1999;47(4):391-6