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Associated Topics

Inconclusive evidence on using antibiotic prophylaxis before dental procedures to prevent infective endocarditis

Mohamed-Nur Abdallah, BDS, MSc, PhD .


Systematic Review Conclusion

Despite the limited evidence and poor methodological quality of many included studies, antibiotic prophylaxis (AP) for patients at highest risk of developing infective endocarditis (IE) is a pragmatic and justified approach. However, postprocedural bacteremia may not be a good surrogate end point for IE.

Critical Summary Assessment

This systematic review found limited evidence that was compromised by many heterogeneous studies with poor methodological quality. Based on the available evidence, no definite conclusion can be reached on the efficacy of AP in preventing IE in patients undergoing dental procedures.

Evidence Quality Rating

Limited Evidence

This summary is published in the Journal of the American Dental Association and can be accessed at:

Critical Summary Publication Date:


These summaries are not intended to, and do not, express, imply, or summarize standards of care, but rather provide a concise reference for dentists to aid in understanding and applying evidence from the referenced systematic review in making clinically sound decisions as guided by their clinical judgment and by patient needs. American Dental Association © 2019