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Associated Topics

Amoxicillin/metronidazole therapy may improve the effectiveness of scaling and root planing in patients with periodontitis: Chronic

L. Virginia Powell DMD, GPR .


Systematic Review Conclusion

Preliminary evidence suggests scaling and root planing (SRP) in combination with amoxicillin (AMX)/metronidazole (MET) (SRP + AMX/MET) therapy may be more effective in treating chronic periodontitis (CP) than is SRP alone.

Critical Summary Assessment

Preliminary evidence from a meta-analysis of four randomized clinical trials (RCTs) seems to support the effectiveness of systemic AMX/MET therapy as an adjunct to SRP alone in treating CP, although safety data are incomplete.

Evidence Quality Rating

Limited Evidence

This summary is published in the Journal of the American Dental Association and can be accessed at:

Critical Summary Publication Date:


These summaries are not intended to, and do not, express, imply, or summarize standards of care, but rather provide a concise reference for dentists to aid in understanding and applying evidence from the referenced systematic review in making clinically sound decisions as guided by their clinical judgment and by patient needs. American Dental Association © 2019