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Associated Topics

Antibiotic prophylaxis reduces infectious complications but increases adverse effects after third-molar extraction in healthy patients

Abdullah Marghalani BDS, MSD .


Systematic Review Conclusion

Antibiotic prophylaxis reduces the risk of experiencing infection, alveolar osteitis and pain after third-molar extractions in healthy adults, but it also results in an increased risk of mild, transient adverse effects.

Critical Summary Assessment

The results of this good systematic review with moderate quality evidence suggest that the attained benefits versus associated risks may not justify the routine use of antibiotic prophylaxis for third-molar extractions in healthy adults.

Evidence Quality Rating

Good Evidence

This summary is published in the Journal of the American Dental Association and can be accessed at:

Critical Summary Publication Date:


These summaries are not intended to, and do not, express, imply, or summarize standards of care, but rather provide a concise reference for dentists to aid in understanding and applying evidence from the referenced systematic review in making clinically sound decisions as guided by their clinical judgment and by patient needs. American Dental Association © 2019