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Adjunct local antimicrobials provide statistically significant benefits over subgingival debridement alone in patients with chronic periodontitis

Robert Durand, DMD, MS, FRCD(C) .


Systematic Review Conclusion

The scientific evidence supports the adjunctive use of local antimicrobials (LAs) with subgingival debridement (SD) in deep or recurrent periodontal sites, mostly with use of vehicles with proved sustained release of the antimicrobial.

Critical Summary Assessment

This was a well-done review of limited evidence for a number of LAs in which there were statistically significant added benefits of using LAs with SD over SD alone. However, the clinical relevance of the added benefits may be questionable, precluding any clear guidelines for their adjunctive use in patients with chronic periodontitis.

Evidence Quality Rating

Limited Evidence

This summary is published in the Journal of the American Dental Association and can be accessed at:

Critical Summary Publication Date:


These summaries are not intended to, and do not, express, imply, or summarize standards of care, but rather provide a concise reference for dentists to aid in understanding and applying evidence from the referenced systematic review in making clinically sound decisions as guided by their clinical judgment and by patient needs. American Dental Association © 2019