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Associated Topics

Amoxicillin/metronidazole therapy may improve the effectiveness of scaling and root planing in patients with periodontitis: Aggressive

L. Virginia Powell DMD, GPR .


Systematic Review Conclusion

Full-mouth scaling and root planing (FMSRP) in combination with amoxicillin (AMX)/metronidazole (MET) (FMSRP + AMX/MET) therapy is more effective in treating generalized aggressive periodontitis (GAgP) than is FMSRP alone.

Critical Summary Assessment

The results of a meta-analysis of six randomized clinical trials (RCTs) of high quality support the use of AMX/MET therapy to increase the effectiveness of FMSRP in treating GAgP.

Evidence Quality Rating

Good Evidence

This summary is published in the Journal of the American Dental Association and can be accessed at:

Critical Summary Publication Date:


These summaries are not intended to, and do not, express, imply, or summarize standards of care, but rather provide a concise reference for dentists to aid in understanding and applying evidence from the referenced systematic review in making clinically sound decisions as guided by their clinical judgment and by patient needs. American Dental Association © 2019