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Associated Topics

Good evidence supports acetaminophen as an effective and safe reliever of acutepostoperative pain

James Zahrowski DMD, MS, PharmD .


Systematic Review Conclusion

A single standard dose of acetaminophen relieves moderate to severe postoperative pain in about one-half of adults for four hours with minimal adverse effects similar to those of placebo.

Critical Summary Assessment

An updated, high-quality systematic review of mostly high-quality evidence indicates that a standard dose of acetaminophen relieves postoperative pain safely for four hours without a dose-dependent effect on efficacy or duration of pain control.

Evidence Quality Rating

Good Evidence

This summary is published in the Journal of the American Dental Association and can be accessed at:

Critical Summary Publication Date:


These summaries are not intended to, and do not, express, imply, or summarize standards of care, but rather provide a concise reference for dentists to aid in understanding and applying evidence from the referenced systematic review in making clinically sound decisions as guided by their clinical judgment and by patient needs. American Dental Association © 2019