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Acetaminophen plus a nonsteroidal anti-inflammatory drug decreases acute postoperative pain more than either drug alone

Ferne Kraglund DDS .


Systematic Review Conclusion

Current evidence suggests that a combination of acetaminophen, also known as paracetamol, and a nonsteroidal anti-inflammatory drug (NSAID) may offer superior analgesia than does either drug alone.

Critical Summary Assessment

The authors of this high-quality review of 21 double-masked randomized controlled trials determined that the combination of acetaminophen and an NSAID reduced acute postoperative (including dental) pain scores and the need for supplemental analgesics more than did acetaminophen or an NSAID alone.

Evidence Quality Rating

Good Evidence

This summary is published in the Journal of the American Dental Association and can be accessed at:

Critical Summary Publication Date:


These summaries are not intended to, and do not, express, imply, or summarize standards of care, but rather provide a concise reference for dentists to aid in understanding and applying evidence from the referenced systematic review in making clinically sound decisions as guided by their clinical judgment and by patient needs. American Dental Association © 2019